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Cialis in the Treatment of Pulmonary Arterial Hypertension

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Complainant alleges that none of these

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The Respondent did not submit any response. Accordingly, the Center notified the Respondent’s default on April�18,�2007. The Center appointed Andrew Mansfield as the sole panelist in this matter on April�30,�2007. The Panel finds that it was properly constituted. The Panel has submitted the Statement of Acceptance and Declaration of Impartiality and Independence, as required by the Center to ensure compliance with the Rules, paragraph 7.

Potential Growth Drivers

Complainant owns the United States Federal trademark CIALIS. The CIALIS mark was registered on the principal register (Registration No. 2,724,589) on June�10,�2003, giving Complainant a constructive use date of June�17,�1999. In addition, Complainant has approximately 130 trademark registrations and applications in approximately 117 nations around the world. The trademark CIALIS designates a pharmaceutical preparation intended for the treatment of erectile dysfunction.

Frequently asked questions

Complainant alleges that Complainant’s decision to use the CIALIS trademark to identify its pharmaceutical product was made public in July�2001. Complainant alleges that Complainant began selling pharmaceutical products identified by the CIALIS mark on January�22,�2003, in the European Union, followed soon thereafter by sales in Australia and New Zealand. Complainant began sales in the United cialis 2 5 mg States in November�2003. Complaint states that the product introduction received significant press coverage worldwide. Complainant alleges that in 2004, Complainant spent approximately $39 million (U.S.) to market and sell its CIALIS brand product worldwide, U.S. factors are applicable in this case.

Product Dosage Quantity + Bonus Price
Cialis Black80mg120 + 8 Pills264.77€ 252.16€
Cialis Generic40mg60 + 6 Pills130.98€ 124.74€
Cialis Super Active20mg270 + 30 Pills661.49€ 629.99€
Cialis Generic20mg360 + 10 Pills427.34€ 406.99€
Cialis Original20mg34 + 2 Pills183.99€ 175.23€
Cialis Super Active20mg90 + 10 Pills314.14€ 299.18€
Cialis Generic40mg360 + 10 Pills477.87€ 455.11€
Cialis Super Active20mg180 + 20 Pills521.59€ 496.75€
Cialis Generic5mg90 + 6 Pills115.91€ 110.39€
Cialis Black80mg360 + 20 Pills639.78€ 609.31€
Cialis Generic5mg20 Pills41.99€ 39.99€
Cialis Black80mg270 + 10 Pills502.88€ 478.93€
Cialis Soft Tabs20mg180 + 8 Pills353.17€ 336.35€
Cialis Generic5mg120 + 6 Pills132.92€ 126.59€
Cialis Professional20mg60 + 2 Pills183.83€ 175.08€
Cialis Professional40mg10 Pills65.09€ 61.99€

Complainant alleges that Respondent registered and is

Storage Parameter Details Recommendations
Temperature 15°C to 30°C Keep away from heat and moisture
Light Keep in original container Protect from light
Humidity Low humidity Store in a dry place
Shelf Life 3 years from manufacturing date Check expiry before use

using the Domain Name in bad faith.

Key Takeaways

For further discussion of these and other risks and uncertainties, see Lilly's filings with the United States Securities and Exchange Commission. Lilly undertakes no duty to update forward-looking statements. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7). Relationship between lower urinary tract symptoms and erectile dysfunction: results from the Boston Area community Health Survey.

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Critical analysis of the relationship between sexual dysfunctions and lower urinary tract symptoms due to benign prostatic hyperplasia. The Complainant is Lilly ICOS LLC, a limited liability company organized under the laws of the State of Delaware, United States of America, represented by Baker & Daniels, United States of America. The Respondent is P F, Box 15, FT Laud, FL 33033, United States of America, of United States of America. The disputed domain name (hereinafter the “Domain Name”) is registered with eNom. The Complaint was filed cialis 10 or 20 with the WIPO Arbitration and Mediation Center (the “Center”) on March�9,�2007.

Regulatory Approvals

On March�9,�2007, the Center transmitted by email to eNom a request for registrar verification in connection with the domain name at issue. On March�15,�2007, eNom transmitted by email to the Center its verification response confirming that the Respondent is listed as the registrant and providing the contact details. The Center verified that the Complaint satisfied the formal requirements of the Uniform Domain Name Dispute Resolution Policy (the “Policy”), the Rules for Uniform Domain Name Dispute Resolution Policy (the “Rules”), and the WIPO Supplemental Rules for Uniform Domain Name Dispute Resolution Policy (the “Supplemental Rules”). In accordance with the Rules, paragraphs 2(a) and 4(a), the Center formally notified the Respondent of the Complaint, and the proceedings commenced on March�26,�2007. In accordance with the Rules, paragraph 5(a), the due date for Response was April�15,�2007. Complainant relies in part on

Parameter Details Notes
Absorption Rapid, within 30-60 minutes Food may delay absorption
Duration of Action Up to 36 hours Variable depending on individual
Metabolism Primarily via CYP3A4 enzyme Liver metabolism
Elimination Half-life Approximately 17.5 hours Long half-life allows flexible dosing

Paragraph 4(b)(iv) of Policy which provides

Country Approval Date Regulatory Body Registration Number Notes
USA 2003 FDA FDA-123456 Patent protected till 2024
European Union 2004 EMA EMA-567890 Marketing authorization granted
Canada 2003 Health Canada HC-789012 Approved for ED and BPH
India 2005 DCGI DCGI-345678 Rapid market access

that evidence of bad faith

About the Company

Complainant urges this Panel to find in accord with those prior Panels. Complainant alleges that Respondent has no rights or legitimate interests in the Domain Name. Complainant points out that the Domain Name appears linked to various commercial websites advertising and selling “Generic” CIALIS brand products, in addition to products which are competitive with Complainant’s product, such as VIAGRA� brand product and LEVITRA� brand product. Complainant alleges on information and belief that Respondent is financially compensated for these links to products that compete with CIALIS. Complainant draws the attention of the Panel to prior Panel decisions that limit the circumstances under which an unaffiliated party may market and sell goods on a website located at a domain name that incorporates or includes a trademark. registration and use is shown when

Society and culture

Back pain and muscle aches usually go away within two days. Not studied for multiple attempts per dose.+ In clinical trials, Cialis for use as needed started to work in 30 minutes for some men who took 20 mg of Cialis for use as needed. When taken as needed, Cialis was shown to improve, up to 36 hours after dosing, the ability of men with ED to have a single successful intercourse attempt. Before taking Cialis, tell your healthcare provider about all your medical problems, particularly if you have or ever had: heart problems such as chest pain (angina), heart failure, irregular heartbeats, or have had a heart attack high or low blood pressure or have high blood pressure that is not controlled retinitis pigmentosa, a rare genetic (runs in families) eye disease severe vision loss, including a condition called NAION a deformed penis shape or Peyronie's disease an erection that lasted more than 4 hours blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia Tell your healthcare provider about all the medicines you take especially if you take: medicines called "nitrates" which are often prescribed for chest pain alpha-blockers often prescribed for prostate problems medicines for HIV or some types of oral antifungal medications some types of antibiotics such as clarithromycin, telithromycin, erythromycin (several brand names exist, please contact your healthcare provider to determine if you are taking this medicine) other medicines or treatments for erectile dysfunction (ED) Cialis is also marketed as Adcirca for the treatment of pulmonary arterial hypertension. Do not take sildenafil citrate (Revatio®)* with Cialis.

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You are encouraged to report negative side effects of prescription drugs to the FDA. protect a man or his partner from sexually transmitted diseases, including HIV serve as a male form of birth control For additional information, talk to your doctor and see full Patient Information at and Prescribing Information at or visit for more information. * The brand listed is a trademark of its respective owner and is not a trademark of Eli Lilly and Company. The maker of this brand is not affiliated with and does not endorse Eli Lilly and Company or its products. About Eli Lilly and Company Lilly, a leading innovation-driven corporation, is developing a growing portfolio of pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations.

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Headquartered in Indianapolis, Ind., Lilly provides answers through medicines and information for some of the world's most urgent medical needs. This press release contains forward-looking statements about the potential of Cialis for the treatment of signs and symptoms of benign prostatic hyperplasia (BPH) and reflects Lilly's current beliefs. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of development, commercialization, and regulatory review. There is no guarantee that Cialis will receive additional regulatory approvals. There is also no guarantee that Cialis will continue to be commercially successful. registration of a domain name

  • Cialis Lilly formulations comply with international pharmacopeial standards.
  • The company has taken steps to reduce environmental impact in manufacturing Cialis.
  • Lilly’s Cialis brand supports scientific publications and training for clinicians.
  • Proper disposal of unused tablets is recommended to avoid unintended exposure.
  • Cialis Lilly aids in improving overall male reproductive health and wellbeing.
  • The brand logo and packaging ensure authenticity against counterfeit products.
  • Partnerships with healthcare providers facilitate access to Cialis Lilly globally.
  • The product is subject to continuous post-marketing surveillance for efficacy and safety.
  • Specialty pharmacies provide additional patient education and monitoring.
  • Cialis Lilly remains a cornerstone treatment in men’s sexual health management.

occurs in order to utilize another’s

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In accordance with the propositions laid down in Oki Data Americas, Inc v. ASD, Inc, WIPO Case No. D2001-0903, and followed in many subsequent cases (see particularly Deutsche Telekom AG v. Mighty LLC/Domain Admin, WIPO Case No. D2005-0027), Respondent could find a safe harbor for the sale of CIALIS� on the website at the Domain Name only if: (i) Respondent is actually offering CIALIS�; (ii) Respondent uses the website to sell only the trademarked goods or services; and (iii) the website accurately discloses Respondent’s relationship (or otherwise) with the trademark owner. well-known trademark by attracting Internet users

Summary of Market and Financial Outlook

sales of the CIALIS brand product totaled more than $206 million (U.S.), and worldwide sales of CIALIS brand product were in excess of $550 million (U.S.). Complainant’s alleged sales of CIALIS brand product exceed $1 billion (U.S.). Complainant alleges that it has an Internet presence, primarily through the website accessed by the domain name , that it uses to advertise and provide information regarding its pharmaceutical product. The domain name was registered by Complainant on August�10,�1999. Complainant alleges that it has used this domain name to identify a website since at least June�2001.

Highest Development Phases

Respondent registered the Domain Name on January�2,�2006. Complainant submits that the CIALIS mark is an invented word that has a high degree of individuality, inherent distinctiveness and no common colloquial use. Complainant further alleges that the Domain Name is confusingly similar to the CIALIS mark. Complainant argues that the addition of a descriptive term to the trademark CIALIS does not lessen the confusing similarity. Further, Complainant presents prior Panel decisions that found that the incorporation of a distinctive mark in its entirety into a domain name creates sufficient similarity between a mark and a domain name to render the domain name confusingly similar. to a website for commercial gain.

  • Cialis Lilly is part of a broader portfolio by Eli Lilly that addresses several medical conditions.
  • Its patent expiration has led to more affordable generics entering the market.
  • Lilly maintains stringent manufacturing standards for Cialis products.
  • Patients should disclose all medications and health conditions before starting Cialis.
  • The brand conducts patient assistance programs for affordability in some regions.
  • Cialis Lilly tablets are scored for easy splitting if needed to adjust dose.
  • Erectile dysfunction can also be influenced by psychological factors; Cialis addresses physical causes.
  • Cialis Lilly must be taken cautiously in patients with heart conditions.
  • Regular medical follow-up is recommended to monitor effectiveness and safety.
  • Cialis Lilly promotes balanced lifestyle as part of overall ED management.

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Contact

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